纳络酮治疗42例昏迷患儿疗效观察

Therapy-effect of Naloxone in 42 children with coma

摘要:

目的 通过观察昏迷患儿临床转归情况，探讨纳络酮对昏迷患儿的治疗作用。方法 各种原因引起的昏迷患儿８２ 例随机分成治疗组（ｎ＝４２）及对照组（ｎ＝４０），对照组给予常规抗感染、利尿脱水、降温镇静等治疗，治疗组在上述治疗基础上加用纳络酮。结果 治疗组的总有效率为５９ ．５ ％ ，对照组为４５ ％ ，差异有显著性（Ｐ＜ ０．０５）；治疗组住院天数较对照组缩短（治疗组１３ ．７±２．１５ｄ，对照组１５．８±２．０５ｄ，Ｐ＜０．０５）。结论 纳络酮治疗昏迷病人有较好疗效，可缩短平均住院日。

Abstract:

Objective To explore Naloxone effect on treating patients with coma through clinical observation of recovery process of the children. Methods 82 children with coma due to various causes were divided into two groups. The control group (n=40) was treated with regular antiinflammation, diuretic, dehydrant, antifebrile and sedatives , while the treatment group (n=42) with Naloxone besides the regular therapy . Results Total effective rate in treatment group was significantly higher than that in control group (59.5% vs. 45%, P<0.05). The in-patient days of treatment group were significantly shorter than of control group (13.7±2.15 d vs. 15.8±2.05 d , P<0.01). Conclusions The finding showed Naloxone was more effective in treating patients with coma and shortened their average days in hospital.