缺氧缺血性脑病新生儿血浆内皮素和降钙素基因相关肽水平动态观察

Dynamic variations of plasma endothelin and calcitonin-genc related peptide levels in neonates with hypoxic-ischemic encephalopathy

摘要:

目的探讨内皮素（ＥＴ）和降钙素基因相关肽（ＣＧＲＰ）在新生儿缺氧缺血性脑病（ＨＩＥ）中的变化及临床意义。方法采用放射免疫法对３６例ＨＩＥ患儿和１８例健康足月新生儿血浆ＥＴ和ＣＧＲＰ水平进行了同期动态测定。结果ＨＩＥ患儿急性期血浆ＥＴ和ＣＧＲＰ水平较恢复期明显增高（Ｐ＜０．０１），并明显高于同期对照组水平（Ｐ＜０．０１），恢复期与正常对照组无显著性差异。急性期不同程度ＨＩＥ及对照组之间ＥＴ，ＣＧＲＰ水平比较表明，重度组明显高于对照组、轻度组及中度组，中度组高于对照组和轻度组，轻度组与对照组无显著性差异。急性期患儿血浆ＥＴ和ＣＧＲＰ呈直线正相关（ｒ＝０．３８，Ｐ＜０．０５）。结论ＥＴ和ＣＧＲＰ参与了新生儿缺氧缺血性脑病的病理生理过程。ＥＴ的增高可能是促发ＨＩＥ脑损伤的一个重要因素，而ＣＧＲＰ增高在ＨＩＥ病程中对脑损伤可能具有一定保护作用。

Abstract:

Objective To study the changes of plasma endothelin (ET) and calcitoningene related peptide (CGRP) levels and their clinical implication in neonates with hypoxic-ischemic encephalopathy (HIE). Methods Dynamic variations of plasma ET and CGRP levels were measured in 36 neonates with HIE and 18 normal neonates by radioimmunoassay method. Results Plasma ET and CGRP levels markedly increased in the acute stage of HIE, especially of severe and moderate groups. ET and CGRP levels in newborn infants with HIE were reduced to normal levels in the convalescence stage. There was a positive correlation between plasma ET and CGRP levels at acute stage of HIE neonates. Conclusions ET and CGRP might be involved in the pathophysiologic process of HIE,CGRP may be play a protective role in HIE.