肺炎支原体肺炎患儿肾脏损害的研究

Kidney impairment in children with mycoplasma pneumoniae pneumonia

摘要:

目的研究肺炎支原体肺炎时尿微量蛋白包括尿ＩｇＧ，白蛋白（Ａｌｂ），β２微球蛋白（β２Ｍ）的变化。方法用放射免疫法分别测定４６例肺炎支原体肺炎患儿急性期尿微量蛋白的变化，并对其中３６例患儿恢复期进行复查，与３０例健康儿童作对照。结果急性期尿ＩｇＧ，Ａｌｂ，β２Ｍ显著高于对照组（Ｐ＜０．０１），并与病情轻重成正比。恢复期尿ＩｇＧ首先恢复（Ｐ＞０．０５），尿Ａｌｂ，β２Ｍ虽明显下降，但仍高于对照组（Ｐ＜０．０５，Ｐ＜０．０１）。结论肺炎支原体肺炎时肾脏受到不同程度的损害，在治疗肺炎同时应注意保护肾功能。

Abstract:

Objective To study the alterations of micro-albuminuria (including IgG, Alb and β 2M) in childten with mycoplasma pneumoniae (MP) pneumonia. Methods Radioimmunoassay was used to detect the alterations of micro-albuminuria of mycoplasma pneumonia at different periods ( 46 cases at the acute period and 36 cases at the recovery period ). Thirty normal children were observed as the control group. Results Microalbuminuria levels of the acute period were significantly higher than those of the normal control group (P<0.01). The increase of micro-albuminuria levels was significantly correlated with exacerbation of the illness. During the recovery period, the level of IgG in the urine was reduced first (P>0.05); although the levels of Alb and β 2M in the urine were reduced obviously, they were still higher than that of the normal control group (P<0.05, P<0.01). Conclusions There are different degrees of kidney impairment in MP pneumonia children. Attention should be paid to protect kidnay function during the treatment of MP pneumonia.