晚发型母乳性黄疸患儿停母乳前后表皮生长因子的变化研究

Changes in epidermal growth factor concentrations in neonates with late-onset breast milk jaundice after stopping breast feeding

摘要:

目的 观察晚发型母乳性黄疸患儿停母乳前后患儿血清及母乳中表皮生长因子（epidermal growth factor，EGF）的变化。方法 选取30例足月晚发型母乳性黄疸患儿为研究对象，收集停母乳72 h前后两次的患儿血清及母乳，分别检测患儿血清中的总胆红素值、EGF浓度及母乳中的EGF浓度。结果 停母乳72 h后患儿血清总胆红素值及EGF浓度较停母乳前显著下降（均P<0.05）；而母乳中EGF浓度在停母乳前后差异无统计学意义（P >0.05）。结论 晚发型母乳性黄疸患儿停母乳前后母乳中EGF浓度无明显变化，而患儿血清中EGF浓度显著下降，其在晚发型母乳性黄疸中的作用及机制有待进一步研究。

Abstract:

Objective To investigate the changes in epidermal growth factor (EGF) concentrations in infants' serum and breast milk in neonates with late-onset breast milk jaundice after stopping breast feeding. Methods Thirty full-term infants with late-onset breast milk jaundice were included in the study. Infants' serum and breast milk were collected before and 72 hours after stopping breast feeding, and the total bilirubin and EGF concentrations in infants' serum and EGF concentration in breast milk were measured respectively. Results At 72 hours after stopping breast feeding, the total bilirubin and EGF concentrations in infants' serum were significantly decreased (P<0.05), but the EGF concentration in breast milk did not show significant change (P >0.05). Conclusions After stopping breast feeding, the neonates with late-onset breast milk jaundice show significant decreases in serum EGF concentration, but the EGF concentration in breast milk shows no significant change. The role and action mechanism of EGF in late-onset breast milk jaundice need further study.