不同控制水平的哮喘患儿呼出气一氧化氮浓度水平及其临床意义

Value of fractional nitric oxide concentration in exhaled breath in assessing level of asthma control in children

摘要:

目的：研究呼出气一氧化氮浓度（fractional nitric oxide concentration in exhaled breath, FeNO）测定技术在辅助评价儿童哮喘控制水平方面的应用价值。方法：将226例哮喘患儿分为哮喘控制组（n=86）、部分控制组（n=63）和未控制组（n=77），90例健康儿童为对照组。采用瑞典尼尔斯（NIOX）呼出一氧化氮测定仪测定哮喘患儿和健康对照儿童FeNO浓度。结果：对照组儿童FeNO浓度为14±6 ppb，控制组为29±26 ppb，部分控制组为32±30 ppb，未控制组为40±32 ppb，3组哮喘患儿的FeNO浓度均高于对照组（P<0.05）；哮喘未控制组患儿FeNO浓度高于控制组（P<0.05）；哮喘部分控制组FeNO浓度与未控制和控制组之间差异无统计学意义。结论：哮喘患儿FeNO水平显著高于健康儿童，且与哮喘控制程度相关。

Abstract:

OBJECTIVE: To investigate the value of fractional nitric oxide concentration in exhaled breath (FeNO) in assessing the level of asthma control in children. METHODS: A total of 226 asthmatic children were divided into controlled asthma (n= 86), partially controlled asthma (n=63), and uncontrolled asthma groups (n=77). Ninety healthy children were enrolled as controls. FeNO was measured for both asthmatic and healthy children using the Swedish-designed NIOX system. RESULTS: The control group had an FeNO of 14±6 ppb, the controlled asthma group had an FeNO of 29±26 ppb, the partially controlled asthma group had an FeNO of 32±30 ppb, and the uncontrolled asthma group had an FeNO of 40±32 ppb. The three asthma groups showed significantly higher FeNO than the control group (P<0.05). The uncontrolled asthma group showed significantly higher FeNO than the controlled asthma group (P<0.05), but there were no significant differences in FeNO between the partially controlled and uncontrolled asthma groups and between the partially controlled and controlled asthma groups (P>0.05). CONCLUSIONS: Asthmatic children have significantly higher FeNO than healthy children, and FeNO is correlated with the level of asthma control.