儿童血清25羟维生素D与肥胖及炎症细胞因子关系的研究

Relationship of serum 25-hydroxyvitamin D with obesity and inflammatory cytokines in children

摘要:

目的：探讨儿童血清25羟维生素D [25-(OH)D3]的水平与肥胖及炎症细胞因子的关系，为临床评估维生素D营养状况与肥胖症的关系提供依据。方法：以2012年2~6月就诊的78例肥胖症儿童为研究对象，并根据年龄、性别等基线情况选取同期进行健康体检的105名儿童作为对照组。抽取空腹静脉血测定血清25-(OH)D3、IL-6、IL-8、IFN-γ、TNF-α。结果：肥胖组儿童25-(OH)D3明显低于对照组（P<0.01）。25-(OH)D3水平与BMI Z-Score呈负相关（r=-0.462，P<0.01）。按血清25-(OH)D3水平将患儿分为维生素D充足组、不足组、缺乏组及严重缺乏组，各亚组间血清IFN-γ水平差异有统计学意义（P<0.05），而血清IL-6、IL-8、TNF-α水平差异无统计学意义。结论：肥胖儿童较正常儿童25羟维生素D水平低；血清维生素D水平与BMI有相关性，但与炎症细胞因子相关性不大。

Abstract:

OBJECTIVE: To study the relationship of serum 25-hydroxyvitamin D [25-(OH)D3] level with obesity and inflammatory cytokines in children, and to provide a basis for clinical evaluation of the relationship between vitamin D nutritional status and obesity. METHODS: Seventy-eight children with obesity who visited the hospital between February and June 2012 were selected as subjects. According to baseline data, such as age and sex, 105 children who underwent physical examination in the same period were selected as controls. Fasting venous blood samples were taken to measure serum levels of 25-(OH)D3, interleukin-6 (IL-6), interleukin-8 (IL-8), interferon-γ (IFN-γ), and tumor necrosis factor α (TNF-α). RESULTS: Serum 25-(OH)D3 levels were significantly lower in the obesity group than in the control group (P<0.01). Serum 25-(OH)D3 levels were negatively correlated with BMI (r=-0.462, P<0.01). Patients were further divided, according to their serum 25-(OH)D levels, into vitamin D sufficiency, vitamin D insufficiency, vitamin D deficiency and severe vitamin D deficiency subgroups. There were significant differences in serum IFN-γ levels among the subgroups (P<0.05). There were no significant differences in serum IL-6, IL-8 and TNF-α levels between the subgroups, however (P>0.05). CONCLUSIONS: Obese children have lower serum 25-(OH)D3 levels than normal children. Serum 25-(OH)D3 level is negatively correlated with BMI, but has little correlation with inflammatory cytokines levels.