朗格汉斯组织细胞增生症儿童肝脏受累的CT表现

CT manifestations of liver involvement in children with Langerhans cell histiocytosis

摘要:

目的：探讨朗格汉斯组织细胞增生症(LCH)儿童肝脏受累的CT表现。方法：回顾性分析9例经临床、实验室、病理检查确诊为LCH肝脏受累患儿的CT表现，其中男6例，女3例，全部病例均行肝脏CT平扫及动脉期、门脉期双期增强CT扫描。结果：9例患儿中， 主要CT表现为肝大（8例）；门静脉周围树枝状低密度灶及“门脉晕征”（7例），增强后动脉期呈轻度至中度强化；肝内胆管扩张（5例）；肝门区及腹膜后淋巴结肿大（4例）；弥漫性低密度小结节灶（3例）,增强后呈环状强化。结论：LCH肝脏受累患儿CT表现具有一定的特点，了解这些特点有助于该病的早期诊断和治疗。

Abstract:

OBJECTIVE: To investigate the computed tomography (CT) manifestations of liver involvement in children with Langerhans cell histiocytosis (LCH). METHODS: Retrospective analysis was performed on 9 LCH children with liver involvement confirmed by clinical, laboratory and pathological examinations to investigate the CT manifestations of this condition. These children, including 6 males and 3 females, had undergone both plain CT scan and dual-phase (the arterial and portal venous phases) contrast-enhanced CT scan. RESULTS: The main CT manifestations included hepatomegaly (8 cases); periportal dendritic hypodense lesions or “periportal halo sign” (7 cases) which were mildly or moderately enhanced in the arterial phase; intrahepatic bile duct dilatation (5 cases); lymphadenopathy in the hepatic hilar or retroperitoneal region (4 cases); and diffuse small hypodense nodules (3 cases), which showed annular enhancement on the contrastenhanced CT scan. CONCLUSIONS: CT findings may be helpful in the early diagnosis and treatment of LCH in children.