粪钙卫蛋白与儿童肠道发育及疾病相关性的研究进展

Research advances in the role of fecal calprotectin in intestinal development and diseases among children

摘要:

钙卫蛋白是S100 蛋白家族中的一种钙、锌结合蛋白，由中性粒细胞表达具有重要的细胞外功能。该文综述了粪钙卫蛋白与儿童肠道发育的相关性及影响因素，以及粪钙卫蛋白在儿童肠道病理状态下如坏死性小肠结肠炎、炎症性肠病、肠道感染、乳糜泻、过敏等疾病的诊断、随访、复发的评估及治疗的反应程度上的应用进展。进一步的研究还需要深入了解粪钙卫蛋白在儿科生理及病理过程中的实际作用。

Abstract:

Calprotectin is a calcium- and zinc-binding protein of the S100 family expressed mainly by neutrophils with important extracellular activity. This paper reviews current findings concerning the relationship between faecal calprotectin and intestinal development among children, influencing factors of fecal calprotectin and the implication of faecal calprotectin in the diagnosis, follow-up, assessment of relapses, and response to treatment in pediatric intestinal diseases, such as necrotizing enterocolitis, inflammatory bowel disease, intestinal infection, celiac disease and allergy. Further studies are required to provide insights into the actual role of calprotectin in physiological and pathological processes in pediatrics.