轻度胃肠炎伴婴幼儿良性惊厥患儿血清硫化氢水平变化的研究

Serum hydrogen sulfide levels in children with benign infantile convulsions associatedwith mild gastroenteritis

摘要:

目的 研究轻度胃肠炎伴婴幼儿良性惊厥(BICE)患儿血清硫化氢(H₂S)水平的变化及意义.方法 选择住院治疗的42 例BICE 患儿为观察组,同期因单纯急性胃肠炎入院治疗的46 例患儿为对照组.使用分光光度计法检测其血清H₂S 水平.结果 观察组患儿血清H₂S 水平显著低于对照组(28±12 μmol/L vs45±10 μmol/L,P<0.O1).惊厥发作次数≥ 2 次患儿血清H₂S 水平显著低于发作次数<2 次患儿(P<0.O5).BICE 患儿惊厥发作次数与血清H₂S 水平呈负相关(r=-0.485,P=0.001);惊厥持续时间≥ 5 min 组患儿的发作时间与血清H₂S 水平呈负相关(r=-0.736,P=0.004).结论 内源性H₂S 水平的降低可能是BICE 患儿发病原因之一;血清H₂S 水平下降程度与惊厥发生的次数及发作超过5 min 的持续时间有关,其临床意义有待于更多的研究证实.

Abstract:

Objective To study the changes and significance of serum hydrogen sulfide (H₂S) levels in childrenwith benign infantile convulsions associated with mild gastroenteritis (BICE). Methods Forty-two hospitalized childrendiagnosed with BICE were recruited to the observation group, and 46 children admitted due to acute gastroenteritis alonewere recruited to the control group. Serum H₂S levels were measured by a spectrophotometer. Results The serumH₂S level in the observation group was significantly lower than in the control group (28±12 μmol/L vs 45±10 μmol/L; P<0.01). The patients with a number of convulsions greater than or equal to two had significantly lower serum H₂Slevels than those with a number less than two (P<0.05). The number of convulsions was negatively correlated withserum H₂S level in BICE patients (r=-0.485, P=0.001). When a convulsion exceeded 5 minues in duration, the durationwas negatively correlated with serum H₂S level (r=-0.736, P=0.004). Conclusions The reduction in endogenous H₂S level might be one of the causes of convulsions in BICE patients. The degree of reduction in H₂S level is associated withthe number of convulsions and the duration of convulsion (when it exceeds 5 minues). Further investigation is needed todetermine the clinical significance of these results.