行为疗法加氟桂利嗪预防性治疗儿童偏头痛效果观察

Preventive effect of behavioral therapy plus flunarizine in children with migraine

摘要:

目的 探讨行为疗法加氟桂利嗪预防性治疗儿童偏头痛的临床效果.方法 2011 年1 月至2014 年1 月就诊的90 名偏头痛患儿随机分为治疗组(45 例)和对照组(45 例),对照组接受口服氟桂利嗪治疗,治疗组采用行为疗法同时口服氟桂利嗪,应用儿童偏头痛残疾程度评分(PedMIDAS)及改良Bussone 头痛指数连续3 个月观察治疗效果.结果 治疗前两组间PedMIDAS 值差异无统计学意义(P>0.05),治疗后3 个月治疗组PedMIDAS 值显著低于对照组(16±8 vs 20±10,P<0.05).治疗前两组间改良Bussone 头痛指数值差异无统计学意义(P>0.05),治疗后3 个月治疗组改良Bussone 头痛指数值显著低于对照组(25±18 vs 37±21,P<0.05).结论 行为疗法加氟桂利嗪预防性治疗儿童偏头痛较单用氟桂利嗪有更好的效果,可考虑临床推广应用.

Abstract:

Objective To investigate the preventive effect of behavioral therapy plus flunarizine in children withmigraine. Methods Ninety pediatric patients with migraine between January 2011and January 2014 were randomlydivided into treatment group (45 cases) and control group (45 cases). The treatment group received behavioral therapy in addition to oral flunarizine, while the control group received oral flunarizine alone. All patients were followed upfor 3 months to evaluate the therapeutic effect by the Pediatric Migraine Disability Assessment Score (PedMIDAS)and improved Bussone headache index. Results There were no significant differences in Ped MIDAS (P>0.05) andimproved Bussone headache index (P>0.05) between the control and treatment groups before treatment. Significantdifferences were observed in PedMIDAS (16±8 vs 20±10; P<0.05) and improved Bussone headache index (25±18 vs37±21; P<0.05) between the two groups after 3 months of treatment. Conclusions Preventive treatment of behavioraltherapy plus oral flunarizine shows a better clinical efficacy than oral flunarizine alone in children with migraine andholds promise for clinical application.