紧密连接蛋白与幽门螺杆菌感染相关性胃病的关系研究

Relationship between tight junction proteins and Helicobacter pylori-associated gastric diseases

摘要:

幽门螺杆菌（Hp）感染是导致慢性胃炎、消化性溃疡的重要原因，但其发病机制尚不清楚。紧密连接结构和功能受损导致胃黏膜屏障功能障碍在Hp 相关性胃病发病中的作用近年来受到关注。紧密连接由多种蛋白及分子组成，包括3 种完整的膜蛋白（咬合蛋白、闭合蛋白、连接黏附分子）和1 种胞浆蛋白（闭合小环蛋白）。该文主要阐述各种紧密连接蛋白的组成及功能，Hp 感染所致紧密连接蛋白功能的变化及其与相关胃病发病的关系，以及增强紧密连接蛋白功能在Hp 相关性胃病防治中的意义。

Abstract:

Helicobacter pylori (Hp) infection is an important cause of chronic gastritis and peptic ulcer, but their pathogenesis is unclear. The role of gastric mucosal barrier dysfunction induced by impaired structure and function of tight junction in the pathogenesis of Hp-associated gastric diseases has received considerable attention in recent years. Tight junction is composed of a variety of proteins and molecules, including 3 integral membrane proteins (occludin, claudins, and junctional adhesion molecules) and a cytoplasmic protein (zonula occludens). This paper mainly describes the composition and function of various tight junction proteins, changes in tight junction protein function induced by Hp infection and their relationship with the incidence of gastric diseases, and the significance of enhancing the tight junction protein function in the prevention and treatment of Hp-associated gastric diseases.