中枢性性早熟对儿童体格及性发育的影响

Effects of central precocious puberty on physical and sexual development in children

摘要:

中枢性性早熟（CPP）是一种青春期发育异常，表现为第二性征提前、骨格成熟和体格提前发育，最终影响儿童的成年身高，甚至可能会产生如恐惧、不安等心理行为问题。目前国际上公认治疗最好的药物为促性腺激素释放激素类似物（GnRHa），其主要目的是改善儿童的最终成年身高；但与此同时，其对患儿的生长发育也存在一些不良反应。该文就CPP及GnRHa治疗对儿童体格及性发育的影响作一综述，以引起临床医师对此疾病及其安全用药的关注。

Abstract:

As abnormal pubertal development, central precocious puberty (CPP) is manifested by the secondary sexual characteristics, skeletal maturation, and physical development in advance. It ultimately affects the adult height of children, even producing some psychological and behavioral problems such as fear and anxiety. Currently, gonadotropin releasing hormone analogue (GnRHa) is recognized as the best medicine worldwide for treating CPP in order to increase children’s final adult height; however, it has some adverse effects on the growth and development of children. This paper reviews the effects of CPP and GnRHa on children's physical and sexual development, with the aim of increasing physicians awareness of this disease and the safety of medication.