血尿酸水平与维吾尔族超重/肥胖儿童青少年代谢综合征的关系

Relationship between serum uric acid level and metabolic syndrome in Uygur children and adolescents with overweight or obesity

摘要:

目的 探讨维吾尔族超重/肥胖儿童青少年的血尿酸（SUA）水平与代谢综合征（MS）之间的关系。方法 研究对象为维吾尔族儿童青少年超重/肥胖患者（n=173）和体重正常者（n=200）。测量其身高、体重、腰围及总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-c）、低密度脂蛋白胆固醇（LDL-c）、空腹血糖及 SUA。结果 超重组和肥胖组的 SUA 水平分别为 235±42、285±42 μmol/L，均明显高于对照组（199±32 μmol/L），差异有统计学意义（P<0.01）。SUA 300~349 μmol/L 组和≥ 350 μmol/L 组超重/肥胖、MS、高血压、血脂异常的检出率均高于 SUA <250 μmol/L 组和 250~299 μmol/L 组（P<0.01）。不同 MS 组分的人群之间 SUA 水平差异有统计学意义，MS 组份增多，SUA 水平增高（P<0.01）。多元回归分析显示：体重指数增加 1 kg/m²，SUA 水平增加 5.74 μmol/L。结论 维吾尔族超重/肥胖儿童青少年的 SUA 水平明显升高；SUA水平升高，MS 及其组分发生率增加；SUA 与体重指数呈正相关。

Abstract:

Objective To study the relationship between serum uric acid（SUA) level and metabolic syndrome（MS) in Uygur children and adolescents with overweight or obesity.Methods A total of 173 Uygur children or adolescents who were either overweight or obese and 200 controls with normal body weight were included in the study. Body weight, height, waist circumference, fasting blood glucose, total cholesterol, high-density lipoprotein cholesterol, lowdensity lipoprotein cholesterol, triglycerides, and SUA were measured. Results The overweight and obesity groups had significantly higher SUA levels（235±42 and 285±42 μmol/L respectively) than the control group（199±32 μmol/L; P<0.01). The subjects with SUA levels of 300-349 μmol/L and ≥350 μmol/L had significantly higher incidence of MS, overweight/obesity, hypertension and dyslipidemia than those with SUA levels of <250 μmol/L and 250-299 μmol/L（P<0.01). There were significant differences in SUA levels between groups with different MS components. SUA level was significantly increased in groups with more MS components（P<0.01). Every 1 kg/m² increment in body mass index（BMI) was associated with 5.74 μmol/L increase in SUA level, according to a multivariate regression analysis.Conclusion Uygur children and adolescents who are either overweight or obese have higher SUA levels than those with normal body weight. The incidence of MS and its components rises with increasing SUA level. BMI has a positive relationship with SUA.