试管婴儿双胎及自然受孕双胎临床分析

Clinical outcomes of twin pregnancies conceived by in vitro fertilization compared with spontaneous twin pregnancies

摘要:

目的 分析试管婴儿双胎与自然受孕双胎产妇和新生儿的临床结局.方法 收集2010 年1 月至2014 年4 月106 例试管婴儿双胎妊娠(试管组)与256 例自然受孕双胎妊娠(对照组)的产妇年龄、妊娠周期、分娩方式、妊娠期合并症、新生儿体格发育、新生儿出生缺陷及新生儿围生期疾病等临床资料,并进行统计学比较分析.结果 试管组产妇平均年龄(32±4 岁)高于对照组(28±4 岁,P<0.05).试管组产妇妊娠期高血压及妊娠期糖尿病发生率均显著高于对照组(均P<0.05).两组新生儿在体格发育、出生缺陷疾病发生率、围生期疾病发病率及病死率等方面比较差异均无统计学意义(均P>0.05).结论 本研究显示试管婴儿双胎与自然受孕双胎围生期结局无明显差异;试管婴儿双胎妊娠的产妇在妊娠期需密切关注血压及血糖的波动情况.

Abstract:

Objective To compare the maternal and perinatal outcomes of twin pregnancies conceived by in vitro fertilization (IVF) with outcomes of spontaneous twin pregnancies. Methods A retrospective analysis was conducted between January 2010 and April 2014 to investigate the maternal age, gestation length, modes of delivery, pregnancy complications and neonatal physical development, birth defects and perinatal diseases in 106 IVF-assisted twin pregnancies (IVF group) and 256 spontaneous twin pregnancies (control group). Results The mothers in the IVF group were significantly older than those in the control group (32±4 years vs 28±4 years, P<0.05). The incidence rates of gestational hypertension and gestational diabetes in the IVF group were significantly higher than in the control group (P<0.05). No significant differences were observed for neonatal physical development, the incidence of birth defects, and the incidence and mortality of perinatal diseases (P>0.05). Conclusions Twins conceived by IVF have similar outcomes as spontaneously conceived twins in the perinatal period. However, special attention is needed to monitor the levels of blood pressure and blood glucose for pregnant women with twins conceived by IVF during prenatal checkups.