孤独症谱系障碍患儿血清25(OH)D水平的检测

Serum levels of 25-hydroxyvitamin D in children with autism spectrum disorders

摘要:

目的 了解孤独症谱系障碍(ASD)患儿维生素D 营养状况,探讨维生素D 水平与ASD 的关系.方法 采用高效液相色谱- 串联质谱法对117 例新诊断的ASD 患儿和109 例健康对照儿童进行血清25(OH)D检测,并根据血清25(OH)D 水平,将维生素D 状况分为正常(>30 ng/mL)、不足(10~30 ng/mL)和缺乏(<10 ng/mL),比较两组儿童维生素D 营养状况.结果 ASD 患儿25(OH)D 水平(19±9 ng/mL)明显低于对照组(36±13 ng/mL), 差异有统计学意义(P<0.01). ASD 患儿中维生素D 缺乏和不足率为89.7%,明显高于对照组(52.3%),差异有统计学意义(P<0.01).结论 ASD 患儿存在维生素D 缺乏或不足,维生素D 缺乏和不足有可能是ASD 发病的环境/遗传因素.

Abstract:

Objective To examine serum 25-hydroxyvitamin D levels in children with autism spectrum disorders (ASD) and to explore the relationship between vitamin D level and ASD. Methods Serum levels of 25-hydroxyvitamin D levels were determined by the HPLC-MS/MS method in 117 children with newly diagnosed ASD and 109 healthy controls. Vitamin D status were classified into normal (>30 ng/mL), insufficiency (10-30ng/mL) and deficiency (<10 ng/mL) according to 25-hydroxyvitamin D levels. Results Serum level of 25-hydroxyvitamin D (19±9 ng/mL) in children with ASD was significantly lower than that in healthy controls (36±13 ng/mL; P<0.01). The rate of vitamin D insufficiency plus deficiency in the ASD group was significantly higher than in the control group (89.7% vs 52.3%; P<0.01). Conclusions Vitamin D insufficiency or deficiency is common in children with ASD and might be as one of the environmental or genetic factors for ASD.