小于胎龄儿与适于胎龄儿化脓性脑膜炎临床特点的比较

Comparison of clinical features of purulent meningitis between small-for-gestationalage and appropriate-for-gestational-age infants

摘要:

目的 探讨小于胎龄儿(SGA)和适于胎龄儿(AGA) 化脓性脑膜炎(PM)临床特征的差异。方法 选取58 例足月新生儿PM 患儿作为研究对象进行回顾性研究。根据出生体重与胎龄,将PM 患儿分为SGA 组(13 例)和AGA 组(45 例)。比较两组临床表现、实验室检查结果及预后的差异。结果 SGA 组的肌张力降低发生率高于AGA 组(P<0.05);SGA 组脑脊液潘氏实验阳性率高于AGA 组(P<0.05);脑部影像学检查提示,SGA 组的脑损伤发生率明显高于AGA 组(P<0.05)。结论 SGA 发生PM 后,脑损伤发生率更高,提示其预后较AGA 更差。

Abstract:

Objective To study the differences in the clinical features of purulent meningitis (PM) between smallfor-gestational-age (SGA) and appropriate-for-gestational-age (AGA) infants. Methods The clinical data of 58 fullterm infants with PM were analyzed retrospectively. The infants were classified into a SGA group (13 cases) and an AGA group (45 cases) according to their birth weight and gestational age. Clinical manifestations, laboratory results, and outcomes were compared between the two groups. Results The incidence of decreased muscle tone in the SGA group was significantly higher than that in the AGA group (P<0.05);the positive rate in the Pandy's test for cerebrospinal fluid in the SGA group was significantly higher than that in the SGA group (P<0.05). Brain imaging examination showed that the incidence of brain injuries in the SGA group was significantly higher than that in the AGA group (P<0.05). Conclusions SGA infants with PM display a higher risk of brain injury, suggesting a poorer outcome, compared with AGA infants.