CYP1A1*2A多态性与儿童急性淋巴细胞白血病易感性的Meta分析

Association between CYP1A1*2A polymorphism and susceptibility to childhood acute lymphoblastic leukemia:a Meta analysis

摘要:

目的 通过Meta 分析,探讨CYP1A1^*2A 基因多态性与儿童急性淋巴细胞白血病(ALL)易感性的关系。方法 制定纳入、排除标准,全面检索中英文数据库(PubMed、OVID 数据库、中国生物医学文献数据库、中国知网和万方数据库),收集CYP1A1^*2A 多态性与儿童ALL 易感性的相关研究(1999 年1 月至2015 年4 月),应用STATA 12.0 软件对纳入文献相关结果进行Meta 分析。结果 最终纳入12 篇文献(英文11 篇,中文1 篇),包含的总病例数为3 355 例。Meta 分析结果显示,CYP1A1^*2A 等位基因模型(OR=1.31,95%CI:1.07~1.61)、显性模型(OR=1.33,95%CI:1.13~1.56)和共显性模型(OR=1.30,95%CI:1.10~1.54)中基因多态性与儿童ALL 易感性相关。基于种族来源的亚组分析结果发现,亚洲人的显性模型(OR=1.57,95%CI:1.19~2.08)和共显性模型(OR=1.61,95%CI:1.20~2.17),以及白种人的等位基因模型(OR=1.31,95%CI:1.04~1.63)和显性模型(OR=1.22,95%CI:1.00~1.49)与增加儿童ALL 发生风险相关。结论 CYP1A1^*2A 多态性可能是儿童ALL 发生的遗传易感因素。

Abstract:

Objective To explore the association between CYP1A1^*2A polymorphism and susceptibility to childhood acute lymphoblastic leukemia (ALL) through a Meta analysis. Methods Inclusion and exclusion criteria were formulated and English and Chinese databases (PubMed, OVID Database, CBM, CNKI, and Wanfang Data) were searched comprehensively. The studies (from January 1999 to April 2015) related to the association between CYP1A1^*2A polymorphism and susceptibility to childhood ALL were collected. STATA 12.0 Software was applied to perform the Meta analysis for the articles included. Results A total of 12 articles were included for analysis (11 English articles and 1 Chinese article), which involved 3 355 cases in total. The results of the Meta analysis showed a significant association between CYP1A1^*2A polymorphism and susceptibility to childhood ALL (allele model:OR=1.31, 95%CI:1.07-1.61;dominant model:OR=1.33, 95%CI:1.13-1.56;codominant model:OR=1.30, 95%CI:1.10-1.54). According to the results of a subgroup analysis based on ethnic origin, an increased risk of childhood ALL was observed in both Asian subgroup (dominant model:OR=1.57, 95%CI:1.19-2.08;codominant model:OR=1.61, 95%CI:1.20-2.17) and the Caucasian subgroup (allele model:OR=1.31, 95%CI:1.04-1.63;dominant model:OR=1.22, 95%CI:1.00-1.49). Conclusions CYP1A1^*2A polymorphism may be associated with the genetic susceptibility to childhood ALL.