DRD2基因rs1079595多态性对学龄儿童注意分散度的影响

Association between rs1079595 polymorphisms in the DRD2 gene and the distractibility based the temperament in school-age children

摘要:

目的 了解DRD2 基因rs1079595 多态性与学龄儿童注意分散度的关系。方法 运用问卷法及DNA 分型技术,分析8~12 岁学龄儿童注意分散度与DRD2 基因rs1079595 多态性的相关性,探讨性别、年龄、分娩方式与基因交互作用对注意分散度的影响。结果 DRD2 基因rs1079595 多态性与儿童注意分散度明显相关,GG/GT 基因型儿童的注意分散度分值(4.3±0.6 分)高于TT 基因型儿童(4.0±0.7 分),差异有统计学意义(P<0.05);rs1079595 多态性与分娩方式的交互作用对儿童注意分散度有影响; 顺产时T 等位基因对儿童注意分散度具有一定保护作用(OR=0.037,P<0.01)。结论 rs1079595 多态性及其与分娩方式的交互作用共同作用于学龄儿童注意分散度。

Abstract:

Objective To study the association between rs1079595 polymorphisms in the DRD2 gene and the distractibility in school-age children. Methods The genotyping at rs1079595 was performed and the distractibility was measured based on the temperament questionnaire in 120 8-12 years old school-age children in order to analyze the effects of the rs1079595 polymorphism and its interaction with the gender, age and delivery mode on the distractibility. Results There was an association between the distractibility and rs1079595 polymorphisms. The distractibility score in children with GG/GT genotypes was significantly higher than in children with the TT genotype (4.3±0.6 vs 4.0±0.7; P<0.05). The interaction between rs1079595 polymorphisms and the delivery mode produced an effect on the distractibility. The normal delivery children with T alleles were associated with a low distractibility (OR=0.037, P<0.01). Conclusions The distractibility based the temperament might be influenced by the rs1079595 polymorphism and its interaction with the delivery mode in school-age children.