奥卡西平的不良反应

Adverse effects of oxcarbazepine

摘要:

奥卡西平(oxcarbazepine, OXC)是一种新型抗癫癎药物,由于其耐受性好,药物间的相互作用少,在临床得到越来越广泛的应用,但其毒副作用仍不可忽视。OXC 的不良反应以中枢神经系统和消化系统多见,如:疲劳、嗜睡、复视、头晕、恶心、呕吐等;皮肤不良反应主要为皮疹;长期服用OXC 还可能引起低钠血症。本文搜集国内外近十年有关OXC 不良反应的文献,并对其进行归纳分析,旨在为OXC 的临床合理用药提供参考。

Abstract:

Oxcarbazepine is a new antiepileptic drug. The results of clinical trials suggest that oxcarbazepine is well tolerated and has less drug interactions. It is being used more and more widely in clinical practice, but its adverse effects should not be ignored. The most common adverse effects of oxcarbazepine are usually related to the central nervous system and digestive system, including fatigue, drowsiness, diplopia, dizziness, nausea and vomit. The common skin adverse reaction is rash. Long-term use of oxcarbazepine may also cause hyponatremia. This article reviews the literature from China and overseas about the adverse effets of oxcarbazepine over the last 10 years in order to find information about rational clinical use of oxcarbazepine.