新生儿呼吸窘迫综合征患儿血清TGF-β1及BMP-7的表达及意义
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Expression profile of TGF-β1 and BMP-7 in serum of preterm infants with respiratory distress syndrome
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    摘要:

    目的 了解新生儿呼吸窘迫综合征(NRDS)患儿血清中TGF-β1和BMP-7的表达趋势, 为临床NRDS的早期防治提供帮助。方法 32例出生后12 h内给予肺表面活性物质(PS)的NRDS早产儿作为PS组; 28例未使用PS的NRDS早产儿作为非PS组; 另外选同期无NRDS的早产儿30例作为对照组。分别于生后0、1、3、7 d采用ELISA检测3组患儿血清中TGF-β1和BMP-7的表达情况。结果 PS组血清TGF-β1表达量在生后1、3 d高于对照组(P<0.05); 非PS组TGF-β1的表达量在生后1、3、7 d明显高于对照组(P<0.05), 生后3、7 d明显高于PS组(P<0.05)。PS组血清BMP-7的表达量在生后1、3 d高于对照组(P<0.05); 非PS组BMP-7的表达量在生后1、3、7 d高于对照组(P<0.05), 生后7 d BMP-7表达量较前有所下降, 但仍高于PS组(P<0.05)。结论 NRDS患儿早期血清TGF-β1和BMP-7的表达均增加, 后期随着血清TGF-β1表达的增加, BMP-7的表达呈下降趋势, 提示给予外源性BMP-7可能降低TGF-β1的表达, 这可能成为治疗NRDS的途径之一。

    Abstract:

    Objective To study the expression profile and significance of serum transforming growth factor-beta 1 (TGF-β1) and bone morphogenetic protein-7 (BMP-7) in preterm infants with respiratory distress syndrome (RDS). Methods Thirty-two preterm infants with RDS who were given pulmonary surfactant (PS) within 12 hours after birth were enrolled as the PS group. Twenty-eight preterm infants with RDS who were not given PS were selected as the non-PS group. Another 30 preterm infants without RDS were used as the control group. Serum levels of TGF-β1 and BMP-7 in the three groups were measured using enzyme-linked immunosorbent assay at 0, 1, 3, and 7 days after birth. Results The PS group had higher serum levels of TGF-β1 than the control group at 1 and 3 days after birth (P<0.05). The non-PS group had significantly higher serum levels of TGF-β1 than the control group at 1, 3, and 7 days after birth (P<0.05), and serum levels of TGF-β1 in the non-PS group were significantly higher than the PS group at 3 and 7 days after birth (P<0.05). The PS group had higher serum levels of BMP-7 than the control group at 1 and 3 days after birth (P<0.05). The non-PS group had higher serum levels of BMP-7 than the control group at 1, 3, and 7 days after birth (P<0.05). The levels of BMP-7 in the non-PS group at 7 days after birth were reduced than before, but were still higher than in the PS group (P<0.05). Conclusions Both serum TGF-β1 and BMP-7 levels increase in the early stage in preterm infants with RDS, however, in the late stage, the expresssion of BMP-7 decreases with the increase in TGF-β1 expression, suggesting that administration of exogenous BMP-7 may reduce the expression of TGF-β1, which might be a therapeutic approach for RDS in preterm infants.

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李小琴, 郑玲芳.新生儿呼吸窘迫综合征患儿血清TGF-β1及BMP-7的表达及意义[J].中国当代儿科杂志,2015,17(5):445-448

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  • 收稿日期:2014-08-20
  • 最后修改日期:2014-11-07
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  • 在线发布日期: 2015-05-15
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