早产儿血清IGF-1 水平与喂养困难的相关性研究

Correlation between serum IGF-1 level and feeding difficulties in preterm infants

摘要:

目的 探究早产儿血清胰岛素样生长因子-1(IGF-1)水平与喂养困难的相关性。方法 回顾性分析2013 年1 月至2014 年1 月出生的200 例早产儿病历资料,分析IGF-1 与早产儿喂养困难的相关性。结果 喂养困难组IGF-1 水平(28±4 ng/mL)明显低于对照组(63±8 ng/mL),差异有统计学意义(P<0.05)。多因素logistic 回归分析显示胎龄大、出生体重大为早产儿喂养困难的保护性因素;窒息、开奶延迟、使用氨茶碱、围生期感染、低IGF-1 水平为早产儿喂养困难的危险因素。结论 早产儿血清IGF-1 水平与喂养困难相关,其水平降低发生喂养困难的风险增大。

Abstract:

Objective To study the correlation between serum insulin-like growth factor-1 (IGF-1) level and feeding difficulties in preterm infants. Methods A retrospective analysis was performed on 200 preterm infants born between January 2013 and January 2014. Venous blood samples were obtained within 24 hours after birth to determine the serum level of IGF-1. The correlation between IGF-1 level and feeding difficulties in preterm infants was analyzed by single-factor analysis and multivariate logistic regression analysis. Results The serum IGF-1 level in the feeding difficulty group was significantly lower than that in the control group (28±4 ng/mL vs 63±8 ng/mL; P<0.05). Results of multivariate logistic regression analysis showed that high gestational age and birth weight were protective factors for feeding difficulties in preterm infants, whereas asphyxia, delayed initiation of feeding, use of aminophylline, perinatal infection and decreased IGF-1 level were risk factors. Conclusions The level of serum IGF-1 is correlated with feeding difficulties in premature infants. A reduced IGF-1 level increases the risk of feeding difficulties.