血清锌与儿童注意缺陷多动障碍关系的Meta分析

Relationship between serum zinc levels and attention deficit hyperactivity disorder in children

摘要:

目的 探讨血清锌与我国儿童注意缺陷多动障碍(ADHD)发生的关系。方法 系统收集2000~2015 年涉及我国儿童ADHD 血清锌水平的病例对照研究文献;采用Stata 12.0 软件对纳入文献进行Meta分析。结果 最终纳入17 篇文献,包括ADHD 病例2 177 例,对照2 900 例。Meta 分析显示,ADHD 组儿童血清锌水平明显低于对照组(合并效应值SMD=-1.33,95%CI:-2.22~-0.44,P=0.003)。敏感性分析显示两组在血清锌水平上的差异结果可靠,Egger's 检验显示无明显的发表偏倚。结论 儿童血清锌水平的下降可能与ADHD 的发生有关。

Abstract:

Objective To study the possible relationship between serum zinc levels and attention deficit hyperactivity disorder (ADHD) in Chinese children.Methods Following a systematic search for case-control studies on the serum zinc levels in Chinese children with ADHD published between 2000 and 2015, a Meta analysis was conducted using Stata 12.0 software.Results A total of 17 studies, including 2 177 children with ADHD and 2 900 normal children, were enrolled. The Meta analysis showed that serum zinc levels in children with ADHD were lower than normal children (SMD=-1.33; 95%CI:-2.22, -0.44; P=0.003). The sensitivity analysis indicated that the results were reliable. Egger's test did not find the existence of publication bias.Conclusions Serum zinc levels may be associated with susceptibility to ADHD in children.