四川绵阳科学城9~11岁儿童高非高密度脂蛋白胆固醇血症现患率调查

Prevalence of a high non-high-density lipoprotein cholesterol level in children aged 9-11 years in Mianyang Science City in Sichuan Province, China

摘要:

目的 调查四川省绵阳市科学城地区9~11 岁儿童非高密度脂蛋白胆固醇（non-HDL-C）的水平和高non-HDL-C 血症现患率。方法 通过整群抽样的调查方法，于2015 年9~10 月对四川省绵阳市科学城地区3 所小学学生进行现场调查，抽取其空腹静脉血，化验血脂四项，计算该地区9~11 岁儿童non-HDL-C 的界值水平、高non-HDL-C 血症的现患率以及肥胖儿童高non-HDL-C 血症的现患率。结果 该地区9~11 岁儿童non-HDL-C 的界值水平为3.67 mmol/L；高non-HDL-C 血症的现患率为3.7%（22/589）。肥胖儿童血清non-HDL-C均值明显高于非肥胖儿童（P < 0.01）；肥胖儿童高non-HDL-C 血症的现患率高于非肥胖儿童（10.0% vs 2.9%，P < 0.01）。结论 该研究建立了四川省绵阳市科学城地区9~11 岁儿童血清non-HDL-C 的界值水平。肥胖与该地区9~11 岁儿童高non-HDL-C 血症现患率增加有关。

Abstract:

Objective To investigate the non-high-density lipoprotein cholesterol (non-HDL-C) level and the prevalence rate of a high non-HDL-C level in children aged 9-11 years in the Mianyang Science City area in Sichuan Province, China. Methods From September to October, 2015, a field investigation was performed for the students from three primary schools in the Mianyang Science City area by cluster sampling. Fasting venous blood was collected for blood lipid tests. The cut-off value of serum non-HDL-C level and prevalence rate of a high non-HDL-C level in children aged 9-11 years in this area were calculated, as well as the prevalence rate of a high non-HDL-C level in obese children. Results In the children aged 9-11 years in this area, the cut-off value of non-HDL-C level was 3.67 mmol/L, and the prevalence rate of a high non-HDL-C level was 3.7% (22/589). Compared with the non-obese children, the obese children had a significantly higher serum non-HDL-C level (P < 0.01) and a significantly higher prevalence rate of a high non-HDL-C level (10.0% vs 2.9%; P < 0.01). Conclusions The cut-off value of serum non-HDL-C level in children aged 9-11 years in the Mianyang Science City area is established. Obesity is associated with an increased prevalence rate of a high non-HDL-C level in children aged 9-11 years.