IL-1β基因C+3953T位点与自发性早产遗传易感性的病例对照研究

Association between interleukin-1β C+3953T and genetic susceptibility to spontaneous preterm birth: a case-control study

摘要:

目的 探讨白细胞介素-1β （IL-1β）基因C+3953T位点与自发性早产 （SPTB）遗传易感性的关联性。方法 病例组样本包括753例SPTB新生儿，对照组包括681例足月新生儿。采用最新的SequenomMassARRAY^®SNP检测技术对IL-1β基因C+3953T位点进行SNP分型。结果 与携带IL-1β基因C+3953T位点的CC基因型的个体相比，携带至少一个T等位基因型 （CT+TT基因型）的个体发生SPTB、合并胎膜早破的SPTB （PPROM）和轻度早产的风险显著升高。结论 在中国人群中，IL-1β基因C+3953T位点与SPTB的患病风险的增加存在显著的遗传学关联。这一SNP位点的发现对于预防SPTB的发生，阐明SPTB的病因和发病机制具有重要意义。

Abstract:

Objective To study the association between interleukin-1β (IL-1β) C+3953T and genetic susceptibility to spontaneous preterm birth (SPTB). Methods In this case-control study, 753 SPTB neonates were enrolled in the case group and 681 full-term neonates were enrolled in the control group. The latest Sequenom MassARRAY^®SNP detection technique was used for the typing of single nucleotide polymorphisms (SNP) of IL-1β C+3953T. Results Compared with those carrying CC genotype of IL-1β C+3953T, the neonates who carried at least one T allele (CT+TT genotype) had significantly increased risks of SPTB, SPTB complicated by premature rupture of membranes, and mild preterm birth. Conclusions In the Chinese population, IL-1β C+3953T has significant genetic association with an increased risk of SPTB. The identification of this SNP helps to prevent SPTB and clarify the causes and pathogenesis of SPTB.