儿童多发性硬化和其他中枢神经系统脱髓鞘疾病诊断标准共识(2012版)解读

An interpretation of consensus statements on diagnostic criteria for multiple sclerosis and demyelinating diseases of the central nervous system in children (2012 version)

摘要:

国际儿童多发性硬化研究小组（IPMSSG）已在2007年提出了对儿童多发性硬化和其它免疫介导的中枢神经系统脱髓鞘疾病的2007版诊断标准（简称“2007版”）。2012年，IPMSSG吸收150名成员的最新研究成果提出了新的诊断标准共识（简称“2012版”）。2012版共识涵盖了儿童急性播散性脑脊髓炎（ADEM）、儿童临床孤立综合征（CIS）、儿童视神经脊髓炎（NMO）和儿童多发性硬化（MS）的诊断标准。作者作为IPMSSG在中国地区仅有的两名成员，在文献基础上，结合临床和科研积累，对2012版共识作一解读，着重体现2012版如何在2007版基础上更加深入、全面地阐述儿童急性中枢神经系统脱髓鞘性疾病的临床特征、诊断标准、影响因素和全新认识等，使其在儿童多发性硬化和其它免疫介导的中枢神经系统脱髓鞘疾病的临床诊治和科研工作中更具有可操作性。

Abstract:

The International Pediatric Multiple Sclerosis Study Group (IPMSSG) put forward the 2007 version of the diagnostic criteria for multiple sclerosis and other immune-mediated demyelinating diseases of the central nervous system in children in 2007 ("2007 version" for short). In 2012, IPMSSG proposed the new diagnostic criteria with reference to the latest research achievements of 150 members ("2012 version" for short). The 2012 version of the consensus statements covers the diagnostic criteria for acute disseminated encephalomyelitis, clinically isolated syndrome, neuromyelitis optica, and multiple sclerosis in children. As the two IPMSSG members in China, the authors give an interpretation of the 2012 version of the consensus statements with reference to related literature and clinical and scientific experience. The authors focus on how the 2012 version comprehensively and thoroughly elaborates on the clinical features, diagnostic criteria, influencing factors, and new ideas of acute demyelinating diseases of the central nervous system in children. These become more operable in clinical diagnosis and treatment of multiple sclerosis and other immune-mediated demyelinating diseases of the central nervous system in children.