肿瘤坏死因子-α G-308A多态性与自发性早产遗传易感性的关联研究

Association between tumor necrosis factor-α G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth

摘要:

目的 探讨肿瘤坏死因子-α（TNF-α）G-308A多态性和自发性早产（SPTB）易感性的关联。方法 收集753例SPTB患儿为病例组，681例足月新生儿为对照组，利用Sequenom MassARRAY^® SNP检测技术对TNF-α基因G-308A多态性位点进行单核苷酸多态性检测。结果 病例组和对照组等位基因G、A分布频率之间的差异无统计学意义（P=0.35）；GG、GA、AA基因型构成比之间的差异也无统计学意义（P=0.64）。Logistic回归分析发现TNF-α基因G-308A位点与SPTB的遗传易感性不相关（OR=0.85，95%CI：0.61~1.19，P=0.35）。结论 TNF-α基因G-308A多态性位点与SPTB遗传易感性不相关。

Abstract:

Objective To study the association between tumor necrosis factor-α (TNF-α) G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth (SPTB). Methods The case group enrolled 753 SPTB infants and the control group included 681 term infants. TNF-α G-308A polymorphisms were genotyped using Sequenom MassARRAY^® SNP. Results The frequencies of the allele (G and A) in the case and control groups were not significantly different (P=0.35). The frequencies of the genotypes (GG, GA and AA) in the case and control groups were not significantly different (P=0.64). The logistic regression analysis found that TNF-α G-308A was not associated with genetic susceptibility to SPTB (OR=0.85; 95%CI:0.61-1.19;P=0.35). Conclusions There is no association between the polymorphisms of TNF-α G-308A and the genetic susceptibility to SPTB.