儿童阅读障碍易感基因研究进展

Research advances in susceptible genes for developmental dyslexia in children

摘要:

儿童发展性阅读障碍（developmental dyslexia）是神经发育障碍性疾病之一，受到多个易感基因的影响。近年来学者们通过染色体分析、全基因组关联研究以及关联分析与基因功能研究、神经影像、神经生理技术相结合等研究方法发现一些阅读障碍易感基因。该文对儿童发展性阅读障碍的易感基因研究进展进行综述。以阅读障碍易感基因研究为起点，为其“基因-大脑-行为”层面的深入研究奠定基础，进而为探究阅读障碍的病因和发病机制提供科学线索。

Abstract:

Developmental dyslexia in children is one of the neurodevelopmental disorders and is affected by various susceptible genes. In recent years, researchers have found some susceptible genes for dyslexia via chromosome analysis, genome-wide association studies, association analysis, gene function research, neuroimaging, and neurophysiological techniques. This article reviews the research advances in susceptible genes for developmental dyslexia, and with the study on susceptible genes for dyslexia, it lays a foundation for in-depth studies on the "gene-brain-behavior" level and provides scientific clues for exploring etiology and pathogenesis of dyslexia.