益生菌在儿童变态反应性疾病中的防治作用

Effect of probiotics in prevention and treatment of allergic diseases in children

摘要:

变态反应性疾病逐年升高的发病率已引起全球的关注,严重危害儿童健康,其共同发病机制是机体对常见的吸入性或食物性过敏原产生以特异性IgE介导的或者细胞介导的免疫反应。流行病学调查、粪便菌群分析和临床研究均提示,变态反应性疾病的发生、发展与早期肠道菌群的紊乱密切相关。益生菌可调节肠道免疫反应、增加上皮细胞屏障功能和抑制病原菌的粘附定植,恢复或重建肠道正常微生物群。随着人们对变态反应性疾病认识的加深,益生菌对其防治作用将越来越受到人们的重视。

Abstract:

The increasing incidence rate of allergic diseases has attracted global attention, and these diseases greatly threaten children's health.The common pathogenesis of allergic diseases is the specific IgE-or cell-mediated immune response to common inhalant or food allergens.Epidemiological investigation, analysis of fecal flora, and clinical studies all suggest that the development and progression of allergic diseases are closely related to the early disturbance of intestinal flora.Probiotics can regulate intestinal immune response, increase the barrier function of epithelial cells, inhibit the adhesion and colonization of pathogenic bacteria, and thus restore or reconstruct normal intestinal flora.With the increasing understanding of allergic diseases, the effect of probiotics in the prevention and treatment of such diseases will be taken more and more seriously.