小儿肥胖与支气管哮喘关联机制的研究进展

Research advances in association between pediatric obesity and bronchial asthma

摘要:

该综述介绍了肥胖引起儿童支气管哮喘在病理生理机制研究方面的进展，包括瘦素在肥胖和哮喘中的关联作用、纤溶酶原激活物抑制剂-1与肥胖和哮喘的相关性、脂联素和白细胞介素与肥胖和哮喘的相关性、神经介质对哮喘的影响作用，并特别介绍以背根感觉神经元伤感器为靶点进而阻断伤感器的信号途径抑制过敏性哮喘的最新研究。

Abstract:

This review article introduces the research advances in the pathophysiological mechanism of obesity in inducing pediatric bronchial asthma, including the role of leptin in obesity and asthma, the association of plasminogen activator inhibitor-1 with obesity and asthma, the association of adiponectin and interleukins with obesity and asthma, and the influence of neurotransmitter on asthma. In particular, this article introduces the latest research on the inhibition of allergic asthma through targeting at the nociceptor of dorsal root ganglion and blocking the signaling pathway of the nociceptor.