呼吸窘迫综合征新生儿治疗后潮气呼吸肺功能检测
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Tidal breathing pulmonary function after treatment in neonates with respiratory distress syndrome
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    摘要:

    目的 探讨不同胎龄以及不同程度的呼吸窘迫综合征 (RDS) 新生儿经治疗后肺功能的情况。方法 107例RDS新生儿分为小于34周早产儿组 (65例),晚期早产儿组 (21例) 及足月儿组 (21例),同时选取121例非RDS患儿作为对照组。根据RDS程度将RDS新生儿分为轻度RDS (1、2级) 及重度RDS (3、4级)。于纠正胎龄44周时行潮气呼吸肺功能测定。结果 不同胎龄RDS新生儿的肺功能参数未见明显差异;RDS组的达峰时间比 (TPEF/tE)、达峰容积比 (VPEF/VE) 较同胎龄对照组小 (P < 0.05);两组不同程度RDS新生儿于纠正胎龄44周时TPEF/tE、VPEF/VE也低于对照组 (P < 0.05),且随着RDS程度加重,其值呈下降趋势。结论 RDS新生儿纠正胎龄44周时肺功能水平明显低于非RDS新生儿;RDS新生儿纠正胎龄44周时潮气呼吸肺功能水平与胎龄无关,主要与RDS严重程度有关。

    Abstract:

    Objective To investigate the pulmonary function after treatment in neonates with respiratory distress syndrome (RDS) at varying disease severity levels and different gestational ages. Methods A total of 107 neonates with RDS were divided into <34 weeks group (65 neonates), late preterm group (21 neonates), full-term group (21 neonates). Another 121 non-RDS children were enrolled as the control group. According to the severity of RDS, the RDS neonates were divided into mild RDS group (grades 1 and 2; 76 neonates), and severe RDS (grades 3 and 4; 21 neonates). The tidal breathing pulmonary function was measured at a corrected gestational age of 44weeks. Results The pulmonary function parameters showed no significant differences across the groups of RDS neonates of different gestational ages; the tidal volume per kilogram of body weight (VT/kg) showed no significant difference between the RDS and non-RDS groups, while the RDS group had significantly higher ratio of time to peak tidal expiratory flow to total expiratory time (tPTEF/tE) and ratio of volume to peak tidal expiratory flow to total expiratory volume (vPTEF/vE) than the non-RDS group of the same gestational age (P < 0.05). At a corrected gestational age of 44 weeks, the two groups of neonates with varying severity levels of RDS had significantly lower tPTEF/tE and vPTEF/vE than the control group (P < 0.05), and tPTEF/tE and vPTEF/vE tended to decrease with the increasing severity level of RDS. Conclusions Neonates with RDS have significantly decreased pulmonary function than those without RDS. At a corrected gestational age of 44 weeks, the tidal breathing pulmonary function in neonates with RDS is not associated with gestational age, but is associated with the severity of RDS.

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吉玲, 马莉雅, 杨赟, 黄娜娜.呼吸窘迫综合征新生儿治疗后潮气呼吸肺功能检测[J].中国当代儿科杂志,2016,18(8):694-697

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  • 收稿日期:2016-02-26
  • 最后修改日期:2016-07-01
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  • 在线发布日期: 2016-08-15
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