早产儿呼吸暂停药物治疗的研究现状分析

Current research status of drug therapy for apnea of prematurity

摘要:

目的 展现近10年来国内外早产儿呼吸暂停 （AOP）药物治疗的研究现状，描绘研究趋势。方法 以主题词“早产儿呼吸暂停”及“治疗”在CNKI数据库、以主题词“apnea of prematurity”及“treatment”在MEDLINE数据库检索2006年1月至2015年12月的文献。筛选文献并提取关键词建立共现矩阵，使用Ucinet 6.2绘制知识图谱。结果 共纳入中文关键词26个，英文关键词20个。中文关键词的共现网络图中居于核心位置的关键词为“早产儿”“呼吸暂停”“原发性呼吸暂停”“纳洛酮”和“氨茶碱”。在英文关键词的共现网络图中，居于核心位置的关键词为“apnea （呼吸暂停）”“preterm infants （早产儿）”和“caffeine （咖啡因）”。结论 目前AOP的药物干预仍以甲基黄嘌呤类为主，国内主要为氨茶碱，而国外则采用咖啡因。其他药物如纳洛酮亦被应用于临床。

Abstract:

Objective To investigate the current status of studies on drug therapy for apnea of prematurity (AOP) in the past decade in China and abroad, and to describe the research trends in the field. Methods CNKI and MEDLINE were searched with the key words "apnea of prematurity" and "treatment" for articles published in the past decade (January 2006 to December 2015). The articles were screened and the key words were extracted to establish the co-occurrence matrix. Ucinet 6.2 was used to plot the knowledge map. Results A total of 26 Chinese key words and 20 English key words were included. Those in the center of the co-existent knowledge map of Chinses keywords were "preterm infants", "apnea", "primary apnea", "naloxone" and "aminophylline"; while "apnea", "preterm infants" and "caffeine" located in the central place of the co-existent knowledge map of English keywords. Conclusions Methylxanthines are still the major drugs for AOP; however, aminophylline is mainly used in China, while caffeine is mainly used in foreign countries. Other drugs such as naltrexone are also used in the clinical treatment of AOP.