百日咳的临床研究进展

Recent progress in clinical research on pertussis

摘要:

百日咳是一种传染性极强的呼吸道传染病。近20年来，许多疫苗高覆盖率的国家出现了“百日咳再现”。百日咳发病率上升的同时，出现了新的流行特征，即年长儿和成人百日咳患病率逐渐上升，他们往往缺乏典型的临床表现，按照现有的百日咳临床诊断标准必定会漏诊大部分患者。该综述就百日咳的流行病学、临床特点、病原学、诊断、治疗、预防现状进行总结，强调对年长儿和成人百日咳患者的识别，提高百日咳的防治水平。

Abstract:

Pertussis is a highly contagious respiratory disease. Despite the high vaccination coverage, re-emergence of pertussis has been reported in many countries over the past two decades. With the increase in the incidence of pertussis, there has been a shift in the epidemiological features:an increased incidence of pertussis has been noted in older children and adults, who normally lack typical clinical manifestations, and who may be easily missed according to current diagnostic references for pertussis. In order to achieve better prevention and treatment of pertussis, this review article summarized the recent research progress in the epidemiology, clinical features, etiology, diagnosis, treatment, and prevention of pertussis, particularly focusing on the diagnosis of pertussis in older children and adults.