抽动障碍患儿血清25羟基维生素D水平的检测

Serum levels of 25-hydroxyvitamin D in children with tic disorders

摘要:

目的 了解抽动障碍（TD）患儿维生素D的营养状况，探讨维生素D水平与TD的关系。方法 选取2016年11月至2017年5月诊断为TD的132例患儿为TD组，其中抽动秽语综合征患儿8例，慢性运动或发声抽动障碍患儿32例，暂时性抽动障碍患儿92例；另选取同期行体检的健康儿童144例为健康对照组。采集两组儿童外周静脉血3 mL，留取血清，采用高效液相色谱-串联质谱法检测两组儿童血清25羟基维生素D[25（OH）D]水平，根据血清25（OH）D水平， > 30 ng/mL为正常、10~30 ng/mL为不足、 < 10 ng/mL为缺乏。结果 TD患儿血清25（OH）D水平明显低于健康对照组（P < 0.01）；TD患儿血清25（OH）D不足或缺乏率明显高于健康对照组（P < 0.01）；暂时性抽动障碍患儿血清25（OH）D水平高于抽动秽语综合征患儿（P < 0.05）。结论 维生素D缺乏或不足可能是导致TD发病的因素之一；且维生素D水平高低可能与TD分型存在关联。

Abstract:

Objective To examine serum 25-hydroxyvitamin D levels in children with tic disorders (TD) and to explore the relationship between vitamin D level and TD. Methods One hundred and thirty-two children who were diagnosed with TD between November 2016 and May 2017 were enrolled as the TD group, including 8 cases of Tourette syndrome, 32 cases of chronic TD, and 92 cases of transient TD. One hundred and forty-four healthy children served as the control group. Peripheral venous blood samples were collected from each child. Serum levels of 25-hydroxyvitamin D were measured using HPLC-MS/MS. The categories of vitamin D status based on serum 25-hydroxyvitamin D level included:normal ( > 30 ng/mL), insufficiency (10-30 ng/mL) and deficiency ( < 10 ng/mL). Results Mean serum level of 25-hydroxyvitamin D in the TD group was significantly lower than that in the control group (P < 0.01). The rate of vitamin D insufficiency or deficiency in the TD group was significantly higher than in the control group (P < 0.01). Mean serum level of 25-hydroxyvitamin D in the transient tic group was higher than in the TS group (P < 0.05). Conclusions Vitamin D insufficiency or deficiency might be associated with the development of TD, and the level of serum 25-hydroxyvitamin D might be related to the classification of TD.