辅助生殖技术出生儿童的青春发育情况调查

A survey of pubertal development in children born with assisted reproductive technology

摘要:

目的 了解辅助生殖技术（ART）出生儿童青春发育状况。方法 回顾性收集1994~2003年北京大学第三医院ART出生儿童的青春发育资料，以“2010年中国学生体质健康调查”横断面研究结果为对照数据，比较二者首次遗精或月经初潮年龄；观察ART出生儿童中超重/肥胖者青春发育情况，并探讨青春发育与体重指数的相关性。结果 纳入ART出生儿童200例，获得有效数据72例，随访率36.0%，其中男性41例，女性31例。ART出生儿童首次遗精平均年龄为13.9岁（95%CI：13.7~14.3岁），月经初潮平均年龄为12.2岁（95%CI：11.8~12.6岁），ART出生儿童首次遗精年龄和月经初潮年龄与正常对照比较差异均无统计学意义。ART出生的男女儿童中超重/肥胖者与正常体重者的首次遗精年龄或月经初潮年龄比较差异无统计学意义。ART出生的儿童超重率、肥胖率与北京市青少年超重率、肥胖率比较差异无统计学意义。ART出生的儿童首次遗精年龄和月经初潮年龄与体重指数均无明显相关性。结论 ART出生儿童青春期发育未出现延迟或提前，与正常对照人群一致；ART出生儿童青春期发育与其青春期体重指数无显著相关性。

Abstract:

Objective To investigate the status of pubertal development in children born with assisted reproductive technology (ART). Methods A retrospective analysis was performed on the pubertal development data of children born with ART in Peking University Third Hospital from 1994 to 2003 (ART group). The data in the cross-sectional study "Reports on the Physical Fitness and Health Research of Chinese School Students in 2010" were used as a control. The age at menarche and the age at spermarche were compared between the two groups. The status of pubertal development in the overweight and obese children in the ART group was evaluated to investigate the correlation between pubertal development and body mass index (BMI). Results A total of 200 children born with ART were enrolled in this study, and 72 of them (41 males and 31 females) completed the survey (response rate=36.0%). In the ART group, the mean age at spermarche and the mean age at menarche were 13.9 years (95%CI:13.7-14.3 years) and 12.2 years (95%CI:11.8-12.6 years), respectively. There were no significant differences in the age at spermarche and the age at menarche between the ART and control groups (P > 0.05). In the ART group, there were no significant differences in the age at spermarche and the age at menarche between the overweight and obese children and the normal weight children (P > 0.05). There were also no significant differences in overweight rate and obesity rate between the children in the ART group and the adolescents in Beijing (P > 0.05). In the ART group, there was no significant correlation between the age at spermarche or menarche and BMI (P > 0.05). Conclusions No delayed or precocious puberty is observed in children born with ART. This is consistent with the normal control data. And there is no significant correlation between pubertal development and BMI in children born with ART.