全反式维甲酸对足细胞损伤保护作用的研究进展

Research advances in the protective effect of all-trans retinoic acid against podocyte injury

摘要:

全反式维甲酸（ATRA）是维生素A类衍生物，在调节细胞聚集、分化、凋亡、增殖及炎症反应中起重要作用。近年来ATRA在肾脏疾病的作用，特别是对足细胞保护作用的研究取得了一定进展。该文就足细胞损伤、ATRA作用特点，以及ATRA诱导足细胞分化及再生、抗增殖与纤维沉积、抑制凋亡等保护作用研究进展作综述。

Abstract:

All-trans retinoic acid (ATRA) is a vitamin A derivative and plays an important role in the regulation of cell aggregation, differentiation, apoptosis, proliferation, and inflammatory response. In recent years, some progress has been made in the role of ATRA in renal diseases, especially its protective effect on podocytes. This article reviews the research advances in podocyte injury, characteristics of ATRA, podocyte differentiation and regeneration induced by ATRA, and the protective effect of ATRA against proliferation, deposition of fibers, and apoptosis.