槐杞黄颗粒对重型肺炎支原体肺炎患儿免疫功能的影响

Effects of Huaiqihuang granules on immune function in children with severe Mycoplasma pneumoniae pneumonia

摘要:

目的 观察槐杞黄颗粒对重型肺炎支原体肺炎患儿免疫功能的影响。方法 将重型肺炎支原体肺炎住院治疗的患儿随机分为两组：槐杞黄治疗组（n=51）和常规治疗组（n=47）。槐杞黄治疗组在常规治疗的基础上口服槐杞黄颗粒，常规治疗组给予常规治疗。观察两组治疗3个月后血清IgA、IgG、IgM水平及T淋巴细胞亚群CD4⁺、CD8⁺百分比及CD4⁺/CD8⁺比值的变化；并比较两组治疗后3个月内再次呼吸道感染的发生率。结果 治疗3个月后槐杞黄治疗组血清IgA、IgG、IgM水平及CD4⁺ T淋巴细胞百分比、CD4⁺/CD8⁺比值明显高于常规治疗组（P  < 0.05）；槐杞黄治疗组CD8⁺ T淋巴细胞百分比明显低于常规治疗组（P  < 0.05）；治疗后3个月内槐杞黄治疗组再次呼吸道感染的发生率明显低于常规治疗组（P  < 0.05）。结论 槐杞黄颗粒具有免疫调节作用，能降低重型肺炎支原体肺炎患儿短期内再次呼吸道感染的发生率。

Abstract:

Objective To observe the effects of Huaiqihuang granules on the immune function in children with severe Mycoplasma pneumoniae pneumonia. Methods Pediatric inpatients with severe Mycoplasma pneumoniae pneumonia were randomly divided into Huaiqihuang granule treatment group (n=51) and conventional treatment group (n=47). The Huaiqihuang granule treatment group was orally administered Huaiqihuang granules in addition to the conventional treatment, while the conventional treatment group received conventional treatment only. Levels of serum IgA, IgG, and IgM, percentages of CD4⁺ and CD8⁺ T lymphocyte subsets, and CD4⁺/CD8⁺ ratio were examined in the two groups. The incidence rate of respiratory tract re-infection within three months following treatment was compared between the two groups. Results The levels of serum IgA, IgG, and IgM, the percentage of CD4⁺ T lymphocytes, and the CD4⁺/CD8⁺ ratio were significantly higher in the Huaiqihuang granule treatment group than in the conventional treatment group three months after treatment (P  < 0.05). In contrast, the percentage of CD8⁺ T lymphocytes was signifcantly lower in the Huaiqihuang granule treatment group than in the conventional treatment group (P  < 0.05). In addition, the incidence rate of respiratory tract re-infection within three months following treatment was signifcantly lower in the Huaiqihuang granule treatment group than in the conventional treatment group (P  < 0.05). Conclusions Huaiqihuang granules can regulate immune functions and reduce the incidence of short-term respiratory tract re-infection in children with severe Mycoplasma pneumoniae pneumonia.