IL-6 C-572G多态性位点与自发性早产遗传易感性的关系

Association between IL-6 C-572G and susceptibility to spontaneous preterm birth

摘要:

目的 探讨IL-6基因C-572G多态性位点与自发性早产（SPTB）遗传易感性的关联性。方法 研究对象来自北京及其周边地区。病例组包括569例SPTB新生儿，其中超早产儿（胎龄 < 28周）56例、极早产儿（胎龄28~31⁺⁶周）166例和中晚期早产儿（胎龄32~36⁺⁶周）347例。对照组包括673例足月新生儿。采用最新的Sequenom MassARRAY^®SNP检测技术对IL-6基因C-572G位点进行单核苷酸多态性分型。结果 与携带IL-6基因C-572G位点的CC基因型的个体相比，携带至少1个G等位基因型（CG+GG基因型）的个体发生中晚期SPTB的风险显著升高（OR=1.35，95%CI：1.01~1.80，P=0.04）。结论 在该中国人群中，IL-6基因C-572G多态性位点与中晚期SPTB患病风险的增加存在显著的遗传学关联。

Abstract:

Objective To investigate the association between the genetic polymorphism of IL-6 C-572G and susceptibility to spontaneous preterm birth (SPTB). Methods The subjects were from Beijing and the surrounding areas of Beijing. This case-control study enrolled 569 SPTB infants, including 56 extremely preterm ( < 28 weeks of gestation), 166 very preterm (28-31⁺⁶ weeks of gestation) and 347 moderate to late preterm infants (32 to 36⁺⁶ weeks of gestation). A total of 673 term infants were enrolled as the control group. The latest Sequenom MassARRAY^®SNP detection technique was used for the typing of single nucleotide polymorphism of IL-6 C-572G. Results Compared with the CC genotypes, the IL-6 C-572G G-positive genotype (CG+GG genotype) was signifcantly associated with an increased susceptibility to moderate to late SPTB (OR=1.35, 95%CI:1.01-1.80, P=0.04). Conclusions Among the Chinese population, IL-6 C-572G polymorphism is associated with susceptibility to moderate to late SPTB.