妊娠期抑郁症与新生儿低出生体重关系的Meta分析

Association between depression during pregnancy and low birth weight in neonates:a Meta analysis

摘要:

目的 探讨妊娠期抑郁症与新生儿低出生体重的关系，为预防新生儿低出生体重提供科学依据。方法 系统收集研究妊娠期抑郁症与低出生体重关系的队列研究文献，进行Meta分析，由两名研究人员独立地提取数据，按照NOS量表对纳入文献进行质量评价，采用Egger's检验评估发表偏倚。结果 共纳入12篇队列研究文献，涉及37 192个样本。Meta分析结果表明：妊娠期抑郁症与新生儿低出生体重有关（Z=2.08，P=0.038），妊娠期抑郁的孕母其新生儿发生低出生体重的风险更高（RR=1.303，95%CI：1.015~1.672）。敏感性分析结果表明该Meta分析结果稳定可靠，Egger's检验结果表明无发表偏倚。结论 妊娠期抑郁症可能是新生儿低出生体重的危险因素。

Abstract:

Objective To study the association between depression during pregnancy and low birth weight in neonates, and to provide a scientific basis for the prevention of low birth weight. Methods Cohort studies on the association between depression during pregnancy and low birth weight were collected and a Meta analysis was performed. Data were extracted independently by two investigators, and quality assessment was performed according to Newcastle-Ottawa Scale. The Egger's test was used to evaluate publication bias. Results A total of 12 cohort studies with 37 192 samples were included. The results of the Meta analysis showed that depression during pregnancy was associated with low birth weight (Z=2.08, P=0.038), and the neonates whose mothers had depression during pregnancy tended to have a high risk of low birth weight (RR=1.303, 95%CI:1.015-1.672). The sensitivity analysis showed that the results of this Meta analysis were stable and reliable, and the Egger's test showed no publication bias. Conclusions Depression during pregnancy may be a risk factor for low birth weight in neonates.