内皮细胞微粒在过敏性紫癜患儿中的表达及意义

Expression and significance of endothelial microparticles in children with HenochSchönlein purpura

摘要:

目的 探讨内皮细胞微粒（EMPs）在过敏性紫癜患儿中的表达及意义。方法 100例初治过敏性紫癜患儿分为紫癜性肾炎组（HSPN组，40例）和非肾炎组（60例），并以30例健康体检儿童为对照组。采用流式细胞术或ELISA方法检测各组血清EMPs、Th17及IL-17的表达或含量。结果 Th17及IL-17在HSP的肾炎组和非肾炎组均高于对照组，以HSPN组最高，差异有统计学意义（P < 0.05）。HSP肾炎组和非肾炎组的EMPs水平较对照组升高，以HSPN组最高，差异有统计学意义（P < 0.05）。紫癜性肾炎组的Th17、IL-17水平与EMPs水平呈正相关（r=0.830、0.644，P < 0.05）。结论 EMPs在过敏性紫癜的发病机制中起一定作用，EMPs升高可能是过敏性紫癜患儿肾脏受累的原因之一。

Abstract:

Objective To study the expression and significance of endothelial microparticles (EMPs) in children with Henoch-Schönlein purpura (HSP). Methods A total of 100 previously untreated children with HSP were classified to Henoch-Schönlein purpura nephritis (HSPN) group (n=40) and non-nephritis group (n=60). Thirty healthy children who underwent physical examination were enrolled as control group. Serum levels of EMPs, T helper 17 cells (Th17), and interleukin-17 (IL-17) were compared between groups. Results The HSPN and non-nephritis groups had significantly higher levels of Th17 and IL-17 than the control group, and the HSPN group had the highest levels (P < 0.05). The HSPN and non-nephritis groups had a significantly higher level of EMPs than the control group, and the HSPN group had the highest level (P < 0.05). In the HSPN group, the levels of Th17 and IL-17 were positively correlated with the level of EMPs (r=0.830 and 0.644 respectively; P < 0.05). Conclusions EMPs play an important role in the pathogenesis of HSP. The increase in EMPs might be one of the reasons for renal involvement in children with HSP.