Jurkat细胞模型在感染性疾病研究中的应用进展

Advances in application of Jurkat cell model in research on infectious diseases

摘要:

感染性疾病可由多种病原体感染人体引起，人体感染病原体后可产生特异性免疫反应。T细胞产生的免疫应答是细胞免疫，在人体抗感染中发挥重要作用，可参与免疫防护及导致免疫病理。各种感染性疾病的转归与细胞免疫功能有密切关系，尤其与T细胞的功能密切相关。Jurkat细胞属于人急性T淋巴细胞白血病细胞系，Jurkat细胞模型可模拟T淋巴细胞功能，在T细胞信号转导、细胞因子和受体表达的体外研究中应用广泛，对各类感染性疾病的治疗和机制研究也具有重要的参考和指导作用。Jurkat细胞模型已广泛应用于病毒性疾病及非典型病原体的体外研究，而使用Jurkat细胞模型的寄生虫感染研究目前仍少见。本文就Jurkat细胞模型在感染性疾病研究中的应用进展进行综述。

Abstract:

Infectious diseases can be caused by multiple pathogens, which can produce specific immune response in human body. The immune response produced by T cells is cellular immunity, which plays an important role in the anti-infection process of human body, and can participate in immunological protection and cause immunopathology. The outcome of various infectious diseases is closely related to cellular immune function, especially the function of T cells. Jurkat cells belong to the human acute T lymphocyte leukemia cell line. Jurkat cell model can simulate the function T lymphocytes, so it is widely used in the in vitro studies of T cell signal transduction, cytokines, and receptor expression, and can provide reference and guidance for the treatment of various infectious diseases and the research on their pathogenesis. The Jurkat cell model has been widely used in the in vitro studies of viral diseases and atypical pathogens, but parasitic infection studies using the Jurkat cell model are still rare. This article reviews advances in the application of Jurkat cell model in the research on infectious diseases.