父母超重/肥胖与子代孤独症谱系障碍的关系

Association between overweight/obesity in parents and autism spectrum disorders in offspring

摘要:

目的 探讨母孕前父母超重/肥胖与子代孤独症谱系障碍（ASD）发生的关系。方法 选取ASD儿童36名（ASD组）及性别、年龄与之相匹配的72名正常儿童（对照组）纳入研究。采用问卷调查的方式收集母亲孕前两组儿童父母身高、体重以及母亲孕期增重等信息，采用单因素和多因素logistic回归法分析母孕前父母超重/肥胖与子代ASD的关系。结果 ASD组母孕前父亲超重/肥胖的检出率高于对照组（56% vs 32%，P=0.018）。单因素和多因素logistic回归分析均显示母孕前父亲超重/肥胖是子代发生ASD的危险因素（分别OR=2.66、2.58，P < 0.05）。结论 母孕前父亲超重/肥胖是子代罹患ASD的独立危险因素，因此在母亲妊娠前，父亲的体重指数应控制在正常范围内，以减少子代ASD的发生。

Abstract:

Objective To study the association between overweight/obesity in parents before maternal pregnancy and the development of autism spectrum disorders (ASD) in offspring. Methods A total of 36 children who were diagnosed with ASD (ASD group) and 72 normal children matched for sex and age (control group) were enrolled. A questionnaire survey was performed to collect the general information, including body height and body weight of parents before maternal pregnancy and maternal weight gain during pregnancy. Univariate and multivariate logistic regression analyses were used to investigate the association between overweight/obesity in parents before maternal pregnancy and ASD in offspring. Results The ASD group had a significantly higher detection rate of overweight/obesity in the father than the control group (56% vs 32%; P=0.018) before maternal pregnancy. The univariate and multivariate logistic regression analyses showed that overweight/obesity of the father before maternal pregnancy was a risk factor for ASD in offspring (OR=2.66 and 2.58 respectively; P < 0.05). Conclusions Overweight/obesity of the father before maternal pregnancy is an independent risk factor for ASD in offspring, and therefore, it is important for the father to control his body mass index within the normal range before maternal pregnancy.