氢质子磁共振波谱在新生儿缺氧缺血性脑病中的应用现状分析

Current status of the application of 1H-magnetic resonance spectroscopy in neonates with hypoxic-ischemic encephalopathy

摘要:

目的 展现氢质子磁共振波谱（¹H-MRS）在新生儿缺氧缺血性脑病（HIE）中应用情况的研究现状，并描绘研究趋势。方法 使用关键词及主题词在PubMed、EMBASE及Web of Science数据库检索2018年1月10日前发表的英文文献，通过严格的纳入及排除标准筛选文献。利用Excel 2016、Bicomb 2.0及VOSviewer1.6.6软件对关键词进行统计，并对热点词汇进行聚类分析及知识图谱绘制。结果 共纳入文献66篇，提取高频关键词27个。结果显示，¹H-MRS在HIE中的应用主要集中在临床和科研两个方面的4个方向中。临床应用中，¹H-MRS作为HIE的临床检查手段及预后判断工具被广泛关注；在科研中，则主要应用于动物实验及与亚低温治疗相关的研究中。结论 ¹H-MRS作为磁共振成像的辅助手段，可在探究新生儿HIE的发病机制、优化现有治疗手段及判断患儿预后方面发挥作用。

Abstract:

Objective To investigate the current status of the application of ¹H-magnetic resonance spectroscopy (¹H-MRS) in neonates with hypoxic-ischemic encephalopathy (HIE), and to describe the trend of research in the field. Methods PubMed, EMBASE, and Web of Science were searched for English articles published up to January 10, 2018, with the combination of key words and MeSH terms. The articles were screened according to inclusion and exclusion criteria. Excel 2016, Bicomb 2.0, and VOSviewer1.6.6 were used to analyze the key words, to perform a cluster analysis of hot words, and to plot the knowledge map. Results A total of 66 articles were included, and 27 high-frequency key words were extracted. The results showed that ¹H-MRS was mainly used in four directions of the clinical practice and scientific research on HIE. In clinical practice, ¹H-MRS attracted wide attention as a clinical examination for HIE and a tool for prognostic evaluation; in scientific research, ¹H-MRS was used in animal experiments and studies associated with mild hypothermia therapy. Conclusions As an auxiliary means of magnetic resonance imaging, ¹H-MRS plays an important role in investigating the pathogenesis of neonatal HIE, improving existing therapies, and evaluating the prognosis of neonates with HIE.