4~12岁哮喘儿童维生素D水平与哮喘控制及肺功能的关系

Association of vitamin D level with asthma control and pulmonary function in asthmatic children aged 4-12 years

摘要:

目的 探讨哮喘儿童血清维生素D水平与哮喘控制及肺功能的关系。方法 纳入150例哮喘患儿为观察组，55例健康儿童为对照组。按哮喘控制水平分级标准将观察组分为良好控制组、部分控制组和未控制组。采用化学发光微粒子免疫检测法检测各组血清25羟维生素D[25（OH）D]水平。根据25（OH）D的水平将哮喘儿童分为维生素D正常组、维生素D不足组和维生素D缺乏组，并对哮喘儿童进行肺功能测定。结果 观察组血清25（OH）D水平显著低于对照组（25±7 ng/mL vs 29±4 ng/mL，P < 0.05）。维生素D正常组、维生素D不足组、维生素D缺乏组哮喘控制率依次降低（P < 0.05），但3组肺功能的比较差异无统计学意义（P > 0.05）。结论 哮喘儿童血清25（OH）D水平较正常儿童降低，且与哮喘控制水平有关，但与肺功能无相关性。

Abstract:

Objective To study the association of vitamin D level with asthma control and pulmonary function in children with asthma. Methods A total of 150 children with asthma were enrolled as observation group, and 55 healthy children were enrolled as control group. According to the level of asthma control, the children were divided into good control group, partial control group, and non-control group. Chemiluminescence microparticle immunoassay was used to measure the serum level of 25-hydroxyvitamin D [25(OH)D] for all groups. According to the level of 25(OH)D, the asthmatic children were divided into normal vitamin D group, vitamin D insufficiency group, and vitamin D deficiency group. Pulmonary function was measured for all asthmatic children. Results The observation group had a significantly lower serum level of 25(OH)D than the control group (25±7 ng/mL vs 29±4 ng/mL; P < 0.05). The normal vitamin D group had the highest asthma control rate, followed by the vitamin D insufficiency group and the vitamin D deficiency group (P < 0.05). There was no significant difference in pulmonary function among the three groups (P > 0.05). Conclusions Asthmatic children have a lower serum level of 25(OH)D than healthy children. The serum level of 25(OH)D is associated with the level of asthma control and has no association with pulmonary function.