儿童抗N-甲基-D-天门冬氨酸受体脑炎免疫治疗进展

Progress in immunotherapy for children with anti-N-methyl-D-aspartate receptor encephalitis

摘要:

抗N-甲基-D-天门冬氨酸受体（NMDAR）脑炎是近年被报道的一种自身免疫性脑炎。目前国内外尚无针对该病的儿童及青少年患者的统一治疗方案，免疫治疗仍是主要的治疗措施，应用较为广泛的包括一线免疫治疗、二线免疫治疗及长程免疫治疗。近年来也有学者尝试应用新型免疫抑制剂或改进现有免疫治疗方案来提高对儿童及青少年患者的治疗效果，该文将尝试总结相关免疫治疗方案，并对免疫治疗研究方向做一展望。

Abstract:

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune encephalitis that was reported in recent years. At present, there remains no unified treatment regimen for the children and adolescents with this disease around the world. Immunotherapy is still the preferred way of treatment, mainly including first-line immunotherapy, second-line immunotherapy, and long-term immunotherapy. In recent years, some researchers have tried new immunosuppressants or modified immunotherapy regimens to improve the treatment outcome of the patients. This article summarizes related immunotherapy regimens, as well as the future direction of research on immunotherapy for anti-NMDAR encephalitis.