循环Alarin在肥胖儿童中的水平及与胰岛素抵抗的相关性

Level of circulating Alarin in obese children and its association with insulin resistance

摘要:

目的 本研究拟探讨循环Alarin在肥胖儿童中的表达水平及与代谢参数的关系。方法 招募体重指数（BMI）高于第95百分位数的肥胖儿童86例为肥胖组，82例年龄和性别与肥胖组匹配的BMI低于第85百分位数的健康儿童作为健康对照组。根据是否发生胰岛素抵抗（IR），将86例肥胖组儿童分为IR组（n=27）和非IR组（n=59）。测量身高、体重、收缩压（SBP）和舒张压（SDP），并计算体重指数（BMI）。检测总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、尿酸（UA）、空腹胰岛素（FINS）及空腹血糖（FBG）水平，并计算葡萄糖和胰岛素曲线下面积（AUC）、稳态模型胰岛素抵抗指数（HOMA-IR）、全身胰岛素敏感性指标（WBISI）。ELISA法检测循环Alarin水平。结果 肥胖组儿童循环Alarin水平较健康对照组显著升高，IR组儿童循环Alarin水平较非IR组显著升高（P < 0.01）。循环Alarin与BMI、TG、FBG、AUC_葡萄糖、AUC_胰岛素、HOMA-IR呈正相关，与WBISI呈负相关（P < 0.05）。循环Alarin的变化与BMI、FBG、HOMA-IR有线性回归关系，其中HOMA-IR对循环Alarin的影响最大（P < 0.05）。结论 循环Alarin水平在肥胖儿童中显著升高，可能与肥胖和IR的发生有关。

Abstract:

Objective To study the level of circulating Alarin in obese children and its association with various metabolic parameters. Methods A total of 86 obese children with a body mass index (BMI) above the 95th percentile were enrolled as the obesity group, and 82 healthy children, matched for age and sex, with a BMI below the 85th percentile were enrolled as the healthy control group. According to the presence or absence of insulin resistance (IR), the obesity group was further divided into an IR group with 27 children and a non-IR group with 59 children. Related anthropometric parameters, including body height, body weight, systolic blood pressure (SBP), and diastolic blood pressure (DBP), were measured, and BMI was calculated. Total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), uric acid (UA), fasting insulin (FINS), and fasting blood glucose (FBG) were measured. The area under the receiver operating characteristic curve (AUC) for glucose and insulin, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), and whole-body insulin sensitivity index (WBISI) were calculated. ELISA was used to measure the level of circulating Alarin. Results The obesity group had a significantly higher level of circulating Alarin than the healthy control group (P < 0.01). The IR group had a significantly higher level of circulating Alarin than the non-IR group (P < 0.01). Circulating Alarin was positively correlated with BMI, TG, FBG, AUC-glucose, AUC-FINS, and HOMA-IR (P < 0.05) and was negatively correlated with WBISI (P < 0.05). The circulating Alarin level had a linear regression relationship with BMI, FBG, and HOMA-IR, among which HOMA-IR had the greatest influence on the circulating Alarin level (P < 0.05). Conclusions There is a significant increase in the circulating Alarin level in obese children, which may be associated with the development of obesity and IR.