新生儿重症监护室环境压力对早产儿神经发育的影响及其表观遗传学研究进展

Research advances in the effect of environmental stress in the neonatal intensive care unit on the neurodevelopment of preterm infants and its epigenetics

摘要:

新生儿重症监护室（NICU）的不良环境刺激会通过表观遗传修饰影响神经发育，对早产儿长期发育结局有不良影响，发育支持干预能逆转基因表观遗传改变而促进早产儿神经发育。该文就NICU压力环境、发育支持干预对早产儿神经发育的影响及其表观遗传效应做一综述，为开展早产儿表观遗传学研究提供参考。

Abstract:

Adverse environmental stimulation in the neonatal intensive care unit (NICU) can affect neurodevelopment through epigenetic modification and thus has adverse effects on the long-term developmental outcome of preterm infants. Developmental care can reverse epigenetic changes in genes and promote neurodevelopment in preterm infants. This article reviews the influence of environmental stress in the NICU and developmental care on neurodevelopment in preterm infants, as well as related epigenetic effects, in order to provide a reference for epigenetic studies of preterm infants.