白噪声联合葡萄糖减轻早产儿视网膜病筛查疼痛的临床研究

Clinical effect of white noise combined with glucose in reducing the pain of retinopathy screening in preterm infants

摘要:

目的 探讨白噪声联合葡萄糖减轻早产儿视网膜病（ROP）筛查操作性疼痛的临床效果。方法 纳入胎龄28~34周，出生体重≤2 000 g的早产儿396例，根据ROP筛查过程中疼痛干预方法的不同随机分为4组：对照组（无白噪声和葡萄糖干预，100例）、白噪声组（96例）、葡萄糖组（98例）、白噪声联合葡萄糖组（102例）。在眼底筛查过程中使用早产儿疼痛量表（PIPP）进行疼痛评分，比较眼底筛查前后4组间的PIPP评分差异。结果 筛查前3 min 4组早产儿的PIPP评分及心率和血氧饱和度均值差异均无统计学意义（P > 0.05）。筛查结束后1 min及5 min白噪声组、葡萄糖组、白噪声联合葡萄糖组的心率及PIPP评分低于对照组，而血氧饱和度高于对照组（P < 0.05）；白噪声联合葡萄糖组的心率及PIPP评分低于白噪声组和葡萄糖组，而血氧饱和度高于白噪声组和葡萄糖组（P < 0.05）。结论 白噪声联合葡萄糖能减轻ROP筛查操作性疼痛，保持早产儿生命体征稳定。

Abstract:

Objective To study the clinical effect of white noise combined with glucose in reducing the procedural pain of retinopathy screening in preterm infants. Methods A total of 396 preterm infants with a gestational age of 28-34 weeks and a birth weight of ≤ 2 000 g were randomly divided into 4 groups according to the intervention method for reducing pain in retinopathy screening:control group with 100 infants (no white noise or glucose intervention), white noise group with 96 infants, glucose group with 98 infants and white noise + glucose group with 102 infants. The Premature Infant Pain Profile (PIPP) was used to determine pain score during retinopathy screening, and the four groups were compared in terms of PIPP score before and after retinopathy screening. Results There were no significant differences in PIPP score, heart rate and blood oxygen saturation between the four groups at 3 minutes before screening (P > 0.05). At 1 and 5 minutes after screening, the white noise, glucose and white noise + glucose groups had significantly lower heart rate and PIPP score but significantly higher blood oxygen saturation than the control group (P < 0.05).The white noise + glucose group had significantly lower heart rate and PIPP score but significantly higher blood oxygen saturation than the white noise and glucose groups (P < 0.05). Conclusions White noise combined with glucose can reduce the procedural pain of retionopathy screening and keep vital signs stable in preterm infants.