新生儿非良性快速性心律失常的心率变异性研究

Heart rate variability in neonates with non-benign tachyarrhythmia

摘要:

目的 分析新生儿非良性快速性心律失常（NNTA）心率变异性（HRV）变化，探讨自主神经系统（ANS）在NNTA中的作用。方法 收集2010年1月至2018年6月间中南大学湘雅二医院新生儿专科住院诊断为NNTA的病例，以同期动态心电图监测为窦性心律或偶发期前收缩的新生儿为对照组，每组又分成早产儿（P-）亚组和足月儿（T-）亚组，对各组临床资料进行回顾性分析。结果 共27例NNTA患儿，占同期新生儿专科住院患儿0.28%（27/9 632），对照组53例。P-NNTA亚组与P-对照亚组、T-NNTA亚组与T-对照亚组比较，窦性RR间期均值标准差（SDANN）显著增高（P < 0.05）。结论 ANS功能不成熟和平衡破坏在NNTA发生发展过程中可能起到重要作用。

Abstract:

Objective To study heart rate variability (HRV) in neonates with non-benign tachyarrhythmia (NNTA) and the role of automatic nervous system (ANS) in NNTA. Methods The neonates who were admitted to the Department of Neonatology, the Second Xiangya Hospital of Central South University, from January 2010 to June 2018 and were diagnosed with NNTA were enrolled as the NNTA group, and the neonates with sinus rhythm or accidental premature beats on ambulatory electrocardiography were enrolled as the control group. Each group was further subdivided into preterm and term subgroups. A retrospective analysis was performed for their clinical data. Results A total of 27 NNTA neonates were enrolled, accounting for 0.28% (27/9 632) of all neonates hospitalized during the same period of time, and 53 neonates were enrolled in the control group. Compared with the preterm and term control subgroups, the preterm NNTA and term NNTA subgroups had a significant increase in the standard deviation of average RR interval (P < 0.05). Conclusions Immature and unbalanced ANS function may play an important role in the development and progression of NNTA.