淋巴细胞亚群绝对计数对儿童难治性肺炎支原体肺炎的早期预测作用

Value of absolute counts of lymphocyte subsets in the early prediction of refractory Mycoplasma pneumoniae pneumonia in children

摘要:

目的探讨淋巴细胞亚群绝对计数对儿童难治性肺炎支原体肺炎（RMPP）的早期预测作用。方法对244例肺炎支原体肺炎（MPP）患儿的临床资料进行回顾性分析。比较普通MPP（166例）和RMPP患儿（58例）的临床特点以及淋巴细胞亚群、乳酸脱氢酶、C反应蛋白、降钙素原、免疫球蛋白E（IgE）等实验室指标，应用ROC曲线评估预测RMMP患者的特异性指标。结果淋巴细胞亚群CD3⁺、CD4⁺、CD19⁺、CD56⁺绝对计数以及血清LDH、CRP、IgE水平两组比较差异均有统计学意义（P < 0.05）。ROC曲线分析显示，CD3⁺、CD4⁺、CD19⁺绝对计数鉴别诊断RMPP和普通MMP的曲线下面积分别为0.866、0.900、0.842，其敏感性分别为86%、90%、82%，特异性分别为75%、70%、80%。结论 CD3⁺、CD4⁺、CD19⁺绝对计数可作为儿童RMPP的预测指标。

Abstract:

Objective To study the value of absolute counts of lymphocyte subsets in the early prediction of refractory Mycoplasma pneumoniae pneumonia (RMPP) in children. Methods A retrospective analysis was performed for the clinical data of 244 children with Mycoplasma pneumoniae pneumonia (MPP). Among these children, 166 had MPP, and 58 had RMPP. The two groups were compared in terms of clinical features and laboratory markers such as lymphocyte subsets, lactate dehydrogenase, C-reactive protein, procalcitonin and immunoglobulin E (IgE). The receiver operating characteristic (ROC) curve was used to evaluate the specific indices for predicting RMMP. Results There were significant differences between the two groups in the absolute counts of CD3⁺, CD4⁺, CD19⁺, and CD56⁺ lymphocytes and the serum levels of lactate dehydrogenase, C-reactive protein, and IgE (P < 0.05). The ROC curve analysis showed that the absolute counts of CD3⁺, CD4⁺ and CD19⁺ lymphocytes had an area under the ROC curve (AUC) of 0.866, 0.900 and 0.842 respectively in the differential diagnosis of RMPP and MPP, with a sensitivity of 86%, 90% and 82% respectively and a specificity of 75%, 70% and 80% respectively. Conclusions The absolute counts of CD3⁺, CD4⁺ and CD19⁺ lymphocytes can be used to predict RMPP in children.