mTOR信号通路在孤独症谱系障碍中的研究进展

Research advances in the role of mTOR signaling pathway in autism spectrum disorder

摘要:

哺乳动物雷帕霉素靶蛋白（mTOR）为细胞内信号通路转导分子，调节很多重要的生理过程。mTOR信号通路在神经系统的突触可塑性、信息传递和加工、神经调控等方面发挥重要作用。mTOR信号通路失调被认为与孤独症谱系障碍（ASD）的发病机制有关，mTOR抑制剂可以改善ASD的症状。本文对mTOR信号通路在ASD发病机制中的作用进行综述，以期为ASD的靶向治疗提供理论依据。

Abstract:

Mammalian target of rapamycin (mTOR) is an intracellular signaling pathway molecule which regulates various fundamental physiological processes. The mTOR signaling pathway plays an important role in synaptic plasticity, information transmission and processing, and neuroregulation. Dysregulation of the mTOR signaling pathway is generally considered to be related to the pathogenesis of autism spectrum disorder (ASD); meanwhile, the mTOR inhibitor can ameliorate the symptoms of ASD. The role of mTOR in the pathogenesis of ASD is summarized in this article to provide a theoretical basis for targeted therapy of ASD.